Adobe: Home of the image editing classic Photoshop, home of Flash, Acrobat and other multimedia and creativity software products.
http://www.adobe.com/

Blender is a free open source 3D modeling program, available for all major operating systems under the GNU General Public License.
http://www.blender.org/

Home of CorelDRAW, PaintShop Photo and other photo editing and digital art software.
http://www.corel.com/

Draw freely with Inkscape, the open source vector graphics editor similar to Illustrator, CorelDraw, or Xara X, using the SVG file format.
http://inkscape.org/

Pencil is a traditional 2D animation and drawing software for Mac OS X, Windows, and Linux. Pencil is free and open source.
http://www.pencil-animation.org/

Open-source graphics software: Xara Xtreme is a powerful, general purpose graphics program for Unix platforms including Linux and Mac OS.
http://www.xaraxtreme.org/

Xara is the home of a number of affordable graphics programs for professionals and novices.
http://www.xara.com/

GIMP is versatile, freely distributed image manipulation program. It works on many operating systems, in many languages, and can be used for a variety of tasks, such as photo retouching, image composition and image authoring.
http://www.gimp.org/